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Medications to Treat Opioid Use Disorder

1. All of the following describe methadone, except for:

A. It is a synthetic opioid agonist.

B. It treats opioid use disorder by preventing any opioid drug from producing rewarding effects such as euphoria.

C. It eliminates withdrawal symptoms and relieves drug cravings.

D. In an opioid-dependent person, treatment doses do not produce euphoria.


2. Which of the following is a good option for patients who do not have ready access to health care or who struggle with taking their medications regularly?

A. Methadone

B. Buprenorphine

C. Naltrexone

D. Any of the above will work for patients who do not have ready access to health care or who struggle with taking their medications regularly


3. Abundant evidence shows that methadone, buprenorphine, and naltrexone all reduce:

A. Opioid use and opioid use disorder-related symptoms.

B. The risk of infectious disease transmission.

C. Criminal behavior associated with drug use.

D. Evidence shows that all three medications reduce opioid use and opioid use disorder-related symptoms, the risk of infectious disease transmission, and criminal behavior associated with drug use.


4. Methadone and buprenorphine are equally effective at reducing opioid use.

A. True

B. False


5. In the cases of serious and long-term opioid use disorder, a patient may need external supports in the form of medication indefinitely.

A. True

B. False


6. Like other opioid medications, buprenorphine and methadone are often misused for the purpose of getting high.

A. True

B. False


7. All of the following pertain to the diversion risk of methadone, except for:

A. Methadone diversion is primarily associated with methadone prescribed for the treatment of opioid use disorders.

B. Evidence suggests that the diversion that occurs is associated with a lack of access to medication.

C. Among those using illicit methadone, the most common reason was a missed medication pick-up.

D. Methadone that is dispensed for use as a pain reliever, not as a substance use disorder medication, is the main source of the medication involved in overdose deaths.


8. Some studies have shown _____ detoxification alone to be associated with increased rates of contracting HIV, so ongoing treatment with this medication is key to reducing transmission of viral infection.

A. Methadone

B. Buprenorphine

C. Naltrexone

D. Detoxification of all three medications have shown an increased associated with contracting HIV


9. It has been demonstrated that the potential of _____ to counteract a neuroinflammatory process that is involved in HIV-associated neurocognitive disorders suggests that this medication could potentially be simultaneously therapeutic for opioid use disorder and HIV.

A. Methadone

B. Buprenorphine

C. Naltrexone

D. Methadone, buprenorphine, and naltrexone all counteract the neuroinflammatory process involved with HIV


10. Compared to single-dose methadone treatment during pregnancy, buprenorphine resulted in:

A. Stabilized fetal levels of opioids, reducing repeated prenatal withdrawal.

B. Increased maternal HIV treatment to reduce the likelihood of transmitting the virus to the fetus.

C. Lower amount of morphine used for NAS treatment.

D. Linking mothers to better prenatal care.


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