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Marijuana and Cannabinoid Neuroscience

1. Which of the following is a “stress-responsive” endocannabinoid?

A. 2-arachidonoylglycerol

B. Anandamide

C. Both (A) and (B)

D. None of the above


2. CB1 receptors are most abundant in immune cells, including microglia, and may mediate some of the anti-inflammatory actions of cannabinoids.

A. True

B. False


3. THC and cannabidiol have opposing effects, and different genetic “strains” have different levels of cannabinoids.

A. True

B. False


4. It is highly unlikely that marijuana causes widespread changes in brain structure, in contract to alcohol.

A. True

B. False


5. Which of the following is true with regard to cannabis use?

A. Cannabis use is associated with cognitive impairment, particularly impairment of verbal learning and memory, and impairment persists following acute intoxication.

B. Cannabis-related cognitive impairment is generally subtle.

C. More frequent, persistent, and earlier onset cannabis use is associated with greater cognitive impairment.

D. All of the above.


6. Which of the following factors can affect the association between adolescent cannabis use and increased risk for psychosis?

A. Early age at first cannabis exposure

B. Frequent / daily use and use of high-potency cannabis

C. Urbanicity

D. All of the above


7. Which of the following is typically anticonvulsant?

A. Cannabidiol

B. Delta-9-tetrahydrocannabinol

C. 2-arachidonoylglycerol

D. Anandamide


8. Cannabinoids seem to be effective at controlling which specific cardinal symptoms of multiple sclerosis?

A. Bladder problems

B. Visual complaints

C. Spasticity and central pain

D. All of the above


9. Tolerance can develop for all effects of cannabis and can be complete for any of the effects.

A. True

B. False


10. Elevation of anandamide / CB1 receptor signaling:

A. Reduces anxiety

B. Increases the extinction of fear

C. Both (A) and (B)

D. None of the above


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