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Lewy Body Dementia (Update)

1. LBD is a rare disorder.

A. True

B. False


2. LBD is a disease associated with abnormal deposits of tau proteins in the brain.

A. True

B. False


3. LBD typically begins at age _____ or older.

A. 40

B. 50

C. 60

D. 70


4. LBD is a progressive disease, meaning symptoms start slowly and worsen over time.

A. True

B. False


5. Lewy bodies affect the _____, which plays a major role in emotions and behavior.

A. Cerebral cortex

B. Hippocampus

C. Limbic cortex

D. Basal ganglia


6. Which of the following symptoms distinguish Lewy Body dementia from other forms of dementia?

A. Visual hallucinations late in the course of dementia.

B. Rapid uncontrolled movements.

C. Paranoia and distrust of others.

D. REM sleep behavior disorder.


7. An accumulation of Lewy bodies is associated with a loss of neurons in the brain that produce:

A. Serotonin

B. Norepinephrine

C. Gamma-aminobutyric acid

D. Acetylcholine


8. Which of the following is considered the greatest risk factor for LBD?

A. Age

B. Genetics

C. Diseases and health conditions

D. Lifestyle


9. All of the following are core characteristics of Lewy Body dementia, except for:

A. Movement problems / Parkinsonism

B. Falls, fainting

C. Visual hallucinations

D. REM sleep behavior disorder


10. Nonvisual hallucinations, such as hearing or smelling things that are not present, are just as common as visual ones - which occur in up to 80% of people with LBD.

A. True

B. False


11. Which of the following is a specific sign of Parkinsonism?

A. Muscle rigidity or stiffness

B. Larger handwriting than was usual for the person

C. A loud voice / shouting

D. Visual hallucinations


12. Those with LBD may suffer from Capgras syndrome, which is when:

A. They think their spouse is having an affair.

B. They believe that relatives long dead are still living.

C. They believe that a relative or friend has been replaced by an imposter.

D. They think that people are taking or hiding things.


13. Clinicians and researchers use the “1-year-rule” to help make a diagnosis.  If cognitive symptoms appear at the same time as or at least a year before movement problems, the diagnosis is dementia with Lewy bodies.  If cognitive problems develop more than a year after the onset of movement problems, the diagnosis is Parkinson’s disease dementia.

A. True

B. False


14. Parkinson’s disease dementia always progresses more quickly than dementia with Lewy bodies.

A. True

B. False


15. Which of the following tests can definitively diagnose LBD?

A. Brain imaging

B. Laboratory studies

C. Neuropsychological tests

D. There are no tests that can definitively diagnose LBD


16. Which of the following act on a chemical in the brain that is important for memory and thinking, and may also improve hallucinations, apathy, and delusions?

A. Cholinesterase inhibitors

B. Norepinephrine and dopamine reuptake inhibitors

C. Tetracyclics

D. Monoamine oxidase inhibitors


17. Carbidopa-levodopa can make it easier to do all of the following, except:

A. Walk

B. Get out of bed

C. Reverse the progress of the disease

D. Move around


18. Because of the side effects of carbidopa-levodopa, physicians may recommend not treating mild movement symptoms with medication.

A. True

B. False


19. Deep brain stimulation can be very effective in treating movement symptoms of:

A. Lewy Body dementia

B. Parkinson’s disease

C. Both LBD and Parkinson’s disease

D. Neither LBD nor Parkinson’s disease


20. All of the following can help address sleep problems without medication, except for:

A. Increasing daytime exercise or activities.

B. Avoiding lengthy or frequent naps.

C. Increasing vitamin D, folate, and niacin intake.

D. Avoiding alcohol, caffeine, or chocolate late in the day.


21. Some anti-anxiety medicines can actually increase anxiety in people with LBD.

A. True

B. False


22. In general, people with LBD benefit from all of the following, except:

A. A consistent schedule

B. Highly stimulating environments

C. Regular exercise

D. Adequate sleep


23. Which of the following can be a good first choice to treat behavioral symptoms?

A. Cholinesterase inhibitors

B. Monoamine oxidase inhibitors

C. Carbidopa-levodopa

D. Selective serotonin reuptake inhibitors


24. Which of the following should not be prescribed for people with LBD because they can cause dangerous side effects?

A. Quetiapine / Seroquel

B. Clozapine / Clozaril, FazaClo

C. Pimavanserin / Nuplazid

D. Haloperidol / Haldol


25. Antipsychotic medications increase the risk of death in all elderly people with dementia but can be particularly dangerous in those with LBD.

A. True

B. False


26. Which of the following should be treated cautiously because certain medications for this condition may worsen cognition or increase confusion?

A. Urinary incontinence

B. Delusions

C. Anxiety

D. REM sleep behavior disorder


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