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HIV AIDS Clinical Care - Adverse Events

Adverse Reactions to HIV Medications

1. Supportive care for gastrointestinal adverse effects include:

A. Reminding the patient to take medications with food if appropriate.

B. Suggesting the use of symptomatic remedies.

C. Prescribing medications such as antiemetics or antidiarrheals if needed.

D. All of the above.


2. All of the following reactions often require discontinuation of the offending medication, except for:

A. Fever

B. Vomiting

C. Liver function abnormalities

D. Rash with mucous membrane involvement


3. Clinical trials have suggested that ginger extract may relieve nausea symptoms.

A. True

B. False


4. In cases of mild rash, it is reasonable to try to identify the offending agent by discontinuing one medication at a time, and a substitution should be made for a discontinued ARV to maintain regimen potency.

A. True

B. False


Drug-Drug Interactions with HIV-Related Medications

5. Integrase inhibitor activity is impaired by polyvalent cations, including all of the following, except:

A. Iron

B. Aluminum

C. Potassium

D. Calcium


6. A drug interaction is definite if:

A. A high level of evidence is available regarding the drug combination.

B. The clinical significance of the interaction is well understood.

C. Consensus exists regarding the management strategy.

D. All of the above.


7. Some patients may obtain which of the following outside the care of their physician and, if unaware of the interactions and suggested dosage adjustments, may be at risk of life-threatening consequences?

A. Erectile dysfunction agents

B. Hypothyroid disorder medications

C. Hypertension medications

D. All of the above


8. Patients should be instructed that which of the following HIV medications in particular have a high potential for significant drug interactions?

A. PIs

B. NNRTIs

C. Cobicistat

D. All of the above


Antiretroviral Medications and Hormonal Contraceptive Agents

9. It has been proven that interactions with ARVs is less likely with contraceptive methods that have primarily local action and minimal systemic absorption, and for injection or transdermal delivery systems, since first-pass metabolism is avoided.

A. True

B. False


10. Small studies of DMPA, or Depo-Provera, have shown significant interactions between DMPA and which of the following?

A. Nelfinavir

B. Efavirenz

C. Nevirapine

D. None of the above


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