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Cannabis Use for Cancer Patients

General Information

1. In the United States, Cannabis is a controlled substance and is classified as a Schedule I agent, meaning it is a drug with a high potential for abuse and no currently accepted medical use.

A. True

B. False


2. Which of the following is a potential benefit of medicinal Cannabis for people living with cancer?

A. Antiemetic effects

B. Appetite stimulation

C. Pain relief

D. All of the above


History

3. The highest expression of the second cannabinoid receptor, CB2, is located on _____, suggesting a possible role in immunity.

A. T lymphocytes and mast cells

B. B lymphocytes and natural killer cells

C. Monocytes and macrophages

D. Granulocytes and dendritic cells


Laboratory / Animal / Preclinical Studies

4. _____, in particular, is thought to have significant analgesic, anti-inflammatory, and anxiolytic activity without the psychoactive effect of delta-9-THC.

A. Cannabidiol

B. Cannabinol

C. Cannabichromene

D. Cannabigerol


5. Cannabinoids may cause antitumor effects by:

A. Induction of cell death

B. Inhibition of cell growth

C. Inhibition of tumor angiogenesis invasion and metastasis

D. All of the above


Human / Clinical Studies

6. After adjusting for age, race, ethnicity, and body mass index, Cannabis use is associated with a 45% reduction in _____ cancer incidence.

A. Lung

B. Colon

C. Bladder

D. Tongue


7. The National Comprehensive Cancer Network Guidelines recommend cannabinoids as breakthrough treatment for chemotherapy-related nausea and vomiting.

A. True

B. False


8. Which of the following have analgesic activity in peripheral tissues?

A. Cannabinoid receptor 1 agonists

B. Cannabinoid receptor 2 agonists

C. Both (A) and (B)

D. None of the above


Adverse Effects

9. Because cannabinoid receptors, like opioid receptors, are located in the brainstem areas controlling respiration, lethal overdoses from Cannabis and cannabinoids may occur.

A. True

B. False


10. Unlike other commonly used drugs, cannabinoids are stored in adipose tissue and exerted at a low rate with a half-life of 1-3 days, so even abrupt cessation of cannabinoid intake is not associated with rapid declines in plasma concentrations that would precipitate severe or abrupt withdrawal symptoms or drug cravings.

A. True

B. False


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