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New Generation Cannabinoid Designer Drugs

Drug Queen of the Web

1. Looking at the different Internet fora, it appears that users:

A. Are conscious of the cannabis-like effects of these herbal blends.

B. Know that the psychoactive properties are mainly due to synthetic cannabinoids.

C. Are aware that these compounds have never been tested for human consumption.

D. All of the above.


2. Online users mostly appreciate Spice products for their psychoactive effects, lack of detection in body fluids, ease of online access, and legal status, although some consumers have reported unpleasant side effects, such as paranoia, cramps, strong headache, mild hallucinations, and vomiting.

A. True

B. False


Why Cannabinoid Designer Drugs are so Popular

3. Spices are referred to as legal highs for all of the following reasons, except:

A. They are not controlled by the 1971 Misuse of Drugs Act.

B. They are licensed for legal use such as alcohol and nicotine.

C. The use and possession of these drugs have been long officially authorized.

D. Their supply is tolerated as long as they are sold for purposes other than human consumption.


4. Apart from the analogs of THC such as _____, the structure of these new synthetic cannabinoids differs from that of THC, so that they probably will not trigger a positive test for cannabinoids in immunoassays of body fluids.

A. HU-210

B. JWH-018

C. JWH-250

D. O-Desmethyltramadol


What Do They Contain?

5. All of the following masking agents of natural origin are commonly added to confuse identification, except for:

A. Vitamin E

B. Eugenol

C. Nicotinic acid

D. Fatty acids


6. Most of the synthetic cannabinoids detected in herbal mixtures have been approved by the US Food and Drug Administration to treat chemotherapy-induced nausea and vomiting.

A. True

B. False


7. Unlike metabolites of most synthetic cannabinoids, _____ hydroxylated metabolites retain in vitro and in vivo activity at CB1 receptors.

A. HU-210

B. JWH-018

C. JWH-250

D. O-Desmethyltramadol


8. The pharmacological effects of HU-210 in vivo are exceptionally long lasting, and in animal models it has been shown to negatively affect:

A. Learning processes

B. Memory processes

C. Sexual behavior

D. All of the above


What Are Their Main Effects?

9. There is an increasing number of clinical reports describing patients presenting for emergency medical care after smoking Spice products with all of the following being the most common symptoms, except for:

A. Profuse sweating

B. Agitation / panic attacks

C. Tachycardia

D. Hallucinations


10. Evidence seems to indicate that Spice products can precipitate psychosis in vulnerable individuals, implying the necessity of advising people with risk factors for psychosis against using synthetic cannabinoids.

A. True

B. False


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