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Roots of Cancer Disparities

1: NCI/CRCHD Grants and Contracts

1. In Fiscal Year 2011, NCI invested over $105 million in health disparities research, training, and integrated networks projects via extramural grants, cooperative agreements, contracts, and supplements overseen by CRCHD.

A. True

B. False


1: Meetings and Trainings

2. CRCHD gathered more than _____ national and international cancer researchers, practitioners, trainees, students, and community activists to share new scientific advances, best practices, and resources at the 2011 Cancer Health Disparities Program Meetings.

A. 60

B. 600

C. 6,000

D. 60,000


1: Products and Resources

3. Historically, NCI’s portfolio has been stronger in basic science and outreach programming and weaker in clinical science research applications.

A. True

B. False


2: Research - Basic Research

4. In 2003, Berg and her team reported that the BP1 gene was active in _____% of the tumors in African American women, compared with 57% of the tumors in white women.

A. 89

B. 72

C. 43

D. 12


5. Cancer risk increases in the 5 to 15 years immediately following pregnancy for Hispanic women.

A. True

B. False


6. Martinez hopes to document whether risk factors associated with cancer are tied to the addition of which type of group at certain DNA regions?

A. Acetyl

B. Phosphate

C. Methyl

D. Ribosyl


7. Which of the following is the most common cancer in young children?

A. Acute lymphoblastic leukemia

B. Brain and other CNS tumors

C. Neuroblastoma

D. Hodgkin lymphoma


8. Estrogen-regulated HER2 increased the risk for CBC among young females and in cases exacerbated by smoking, there was a _____% increase in risk.

A. 50

B. 90

C. 120

D. 150


9. Recent use of the injectable contraceptive for at least a year was associated with a doubling of breast cancer risk in young women.

A. True

B. False


2: Basic Research

10. Eupalmerin acetate, is extracted from which species abundant in the Caribbean and appears capable of targeting gliomas, the most common form of primary brain cancer?

A. Fish

B. Sponges

C. Algae

D. Corals


11. The Optimized Nanoparticle Vaccines for Prostate Cancer are working to design nanoparticles to find tumor cells by targeting them to which type of receptor on the cell surface?

A. Glucose

B. Mannose

C. Xylose

D. Ribose


2: Applied Research

12. Principal investigator Grace Ma partnered with other researchers and the community to educate community members on hepatitis C screenings and follow-ups.

A. True

B. False


13. CNP-Appalachia provided information to community members encouraging which type of test?

A. Colonoscopy

B. Prostate exam

C. Mammogram

D. None of the above


14. CNP-Southern California in Fullerton, set out to tailor educational resources to meet the needs of the Hispanic population for cancer screening exams.

A. True

B. False


15. Almost _____% of Bethel’s women use Iqmik and/or other forms of tobacco during pregnancy to the detriment of both mother and fetus.

A. 80

B. 60

C. 40

D. 20


16. Which Asian American group has the highest mortality rate among women due to breast cancer?

A. Chinese

B. Japanese

C. Korean

D. Filipino


17. CNP-Northern California found that the intervention that used only the kit and brochures led to a significantly greater increase in the number of colorectal screenings compared to the intervention with added telephone counseling.

A. True

B. False


18. CNP-Tampa Bay trained which occupational worker to deliver prostate cancer health education?

A. Bankers

B. Barbers

C. Grocery clerks

D. All of the above


19. CNP-North Carolina determined that individual who are established, reliable members of a community’s life, such as hairdressers, are perhaps the most effective advocates for encouraging health behavior changes.

A. True

B. False


20. CNP-Georgia developed a worksite breast health program for the community of more than _____ employees of the world’s busiest airport.

A. 1,200

B. 8,900

C. 23,000

D. 56,000


21. MB-CCOP-Tennessee worked with African American patients newly diagnosed with cancer and managed to accrue _____% of them to clinical trials, compared with the national accrual rates of between 2-4%.

A. 8

B. 14

C. 19

D. 25


22. CNP-North Carolina’s Project CONNECT focused on developing, evaluating, and improving clinical trial communication tools, increasing diversity of participants in local clinical trials, and building local awareness and acceptability of research participation.

A. True

B. False


23. CNP-Missouri discovered that the black community holds a deep distrust for the healthcare establishment and do not believe in the importance of medical research.

A. True

B. False


24. CNP-Washington State has begun epidemiological studies of which virus?

A. HPV

B. HIV

C. HBV

D. HCV


25. Biobanks serve as central repositories where biospecimens are sorted, inventoried, and stored.

A. True

B. False


26. Maryland Senate Bill 283 established a three-year program for breast cancer screening, referral, and treatment for uninsured/economically disadvantaged women in rural Charles County, MD.

A. True

B. False


27. House Bill 895 HD2 (2009) increases the tax on all tobacco products other than cigarettes to _____% of the wholesale price, with a portion of the proceeds going toward lung cancer screening.

A. 80

B. 60

C. 40

D. 20


2: Applied Research

28. NCI-CRCHD supported the development and evaluation of patient navigation interventions at eleven academic research sites across the country, with a twelfth additional site funded by the American Cancer Society.

A. True

B. False


29. In the past, there were different clinical staff calling the patient regarding the abnormal result, and now there is one central person, known as:

A. The patient coordinator

B. The patient navigator

C. The clinical coordinator

D. The clinical results navigator


3: Diversifying the Cancer Biomedical Workforce

30. The probability of black scientists securing NIH R01 grants was 13.2% lower than that of white scientists during the 2000 - 2006 fiscal years.

A. True

B. False


31. The NCI CURE program offers support at which levels:

A. High school and undergraduate

B. Pre-doctoral and post-doctoral

C. Early stage investigator

D. All of the above


32. CURE is the first and only NIH program to offer long-term, continuous training support to underrepresented students and professionals.

A. True

B. False


33. In FY 2011, of the 180 diversity supplements awarded, which educational level received the most?

A. High school

B. Graduate

C. Postdoctoral

D. Junior faculty


34. ET CURE funds research experiences for young people in elective areas centered on emerging and advanced technologies in all of the following except:

A. Clinical proteomics

B. Biophotonics

C. Epidemiology

D. Genomics


35. Temesgen Woldeyesus, an ET CURE UC Davis student, proposed a DNA nanocarrier made of iron oxide nanoparticles, which can be manipulated inside the body via which method?

A. pH changes

B. Temperature changes

C. Electromagnetic fields

D. None of the above


36. The targeting of which protein allows cancer drugs to kill tumor cells by apoptosis?

A. MCL-1

B. p53

C. MAPK

D. MTOR


37. Ruidiaz used the polyclonal antibody, alemtuzumab (anti-CD52), as a developmental model for assay refinement in patients with chronic lymphocytic leukemia.

A. True

B. False


38. In addition to diversity supplements, CURE offers four Career Development Awards.

A. True

B. False


39. Of the 71 mentored and nonmentored career development grants in FY 2011, 38% were awarded to female grantees.

A. True

B. False


40. Which of the following was not among the most frequently studied cancer types?

A. Lung

B. Liver

C. Hematologic

D. Colorectal


41. Mentorship is routinely cited by grantees as among the most valuable features of the K-series training awards.

A. True

B. False


42. Doubeni’s initial diversity supplement documented increases in the use of mammography in breast cancer survivors over time.

A. True

B. False


43. Schildkraut is a long-time NCI grantee whose research focuses on genetic risk factors in women with which type of cancer?

A. Breast

B. Lung

C. Ovarian

D. Colorectal


44. Winn found that the activation of which pathway has a positive effect on the prevention of early lung cancer in smokers?

A. The MTOR pathway

B. The prostacyclin pathway

C. The PI3K pathway

D. The AKT pathway


45. Tonya Webb’s studies focused on which cell type?

A. Hepatocytes

B. Enterocytes

C. Memory B cells

D. Natural killer T cells


46. STEP-UP, a summer internship program, is aimed at high school students and focuses on developing their biomedical science background.

A. True

B. False


47. CNP-Texas identified a critical point at which many diverse, early-stage investigators lose confidence and/or drop out of research careers - the transition between which two levels?

A. High school to the bachelor level

B. Bachelor to masters level

C. Masters to doctoral level

D. Doctoral to postdoctoral level


4: Linking Research, Training, and Outreach

48. CRCHD’s cancer health disparities research and diversity training flagship programs across how many regions?

A. 4

B. 6

C. 8

D. 10


49. Which region focuses its efforts on colorectal cancer?

A. 4

B. 5

C. 6

D. 7


50. The book, “The Immortal Life of Henrietta Lacks,” tells the story of how scientists took cancerous cell tissue from an African American women without her knowledge or consent and cultured it to create an immortal human cell line used in numerous medical research studies.

A. True

B. False


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