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1. While historically, benzodiazepines seemed to be a model medication for the management of symptoms related to PTSD, reports began to appear about potential withdrawal symptoms and risks of tolerance and dependence, which contributed to the continued controversy surrounding their use.
A. True
B. False
2. Which of the following is an accurate statement about the current use of benzodiazepines to treat PTSD?
A. The 2010 U.S. Department of Veterans Affairs (VA) and the U.S. Department of Defense (DoD) Clinical Practice Guideline (CPG) summarizes numerous research findings that caution providers against the use of benzodiazepines to treat PTSD
B. No data support the efficacy of benzodiazepines for the treatment of what is considered “core” PTSD symptoms such as avoidance, hyperarousal, numbing, or dissociation
C. Despite the recommendation against their use, prescribing of benzodiazepines for Veterans with PTSD remains at about 25 % in the VA
D. Benzodiazepines are recommended in conjunction with cognitive-behavioral therapy (CBT) to treat those with PTSD and anxiety disorders
3. While some clinicians think that by allowing patients to take benzodiazepines only on an as-needed basis, they can avoid the physiological dependence associated with them, others report that this actually can lead to fluctuating blood levels that can worsen anxiety and cognitive impairment.
A. True
B. False
4. One clinical trial with alprazolam showed no benefit in alleviating PTSD symptoms compared with placebo, and another that compared clonazepam with placebo for PTSD-related sleep dysfunction found no difference between benzodiazepine and placebo treatments.
A. True
B. False
5. Two common and frequently under-diagnosed comorbidities among Veterans with PTSD include substance use disorders and __________________, which are both contraindications to benzodiazepine use.
A. Chronic sleep disturbances
B. Bipolar disorder
C. Mild traumatic brain injury
D. Urologic injuries
6. The alpha-1 blocker, ___________, used to treat hypertension, is considered to have some benefit for targeting PTSD-related sleep problems and nightmare symptoms.
A. Trimazosin
B. Doxazosin
C. Terazosin
D. Prazosin
7. When gender comparisons were made, male Veterans with PTSD were more likely than females to receive medications across all classes of drugs.
A. True
B. False
8. There is still a tremendous need for research to find new medications to manage PTSD, particularly since the two currently recommended first-line agents that effect neurotransmitters are estimated to help only about one-third of the people who take them.
A. True
B. False
9. In addition to findings indicating that long-term harms imposed by benzodiazepine use outweigh any short-term symptomatic benefits for PTSD, a cultural change has occurred in psychotherapy showing movement from supportive group treatment to evidence-based cognitive behavioral psychotherapies.
A. True
B. False
10. The risk-to-benefit ratio of benzodiazepine use remains positive in most patients for a period of ____________, but is unestablished beyond that time.
A. 2 to 4 weeks
B. 4 to 6 weeks
C. 6 to 8 weeks
D. 8 to 10 weeks
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